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Newswise — Washington, D.C.—A new paper describes a study of antimicrobial resistance (AMR) transmission among cockroaches, with implications for AMR transmission in humans. The study was published in mSystems, a journal of the American Society for Microbiology.
AMR represents a serious threat to the health of humans and other animals. With fewer and fewer drugs being effective against some microbial pathogens, infections have become increasingly difficult to treat. Theoretical modeling has been used to explore the spread of AMR through the microbiome of the symbiotic, or nonpathogenic, gut of animals. The present study represents a real-world investigation.
Gregarious insects such as cockroaches permit a simple, easily maintained experimental system to test microbial transmission of AMR. Many cockroach species live in dense groups and have frequent contact, parallel to humans living in urban environments. Researchers added tetracycline to the diet of a population of socially interactive cockroaches. Tetracyclines are a class of antibiotics that treat several kinds of bacterial infections. They observed an increase in abundance of tetracycline resistance genes in their gut microbiomes.
The researchers at the Technical University of Denmark then allowed an untreated population of cockroaches to mix with the tetracycline-treated ones. After interaction with treated cockroaches, the untreated ones also displayed elevated resistance to tetracycline, as did the soil substrate in the habitat which housed the cockroaches. The levels of tetracycline resistance depended on the extent and the frequency of interaction between treated and untreated cockroach populations.
The results of the study illustrate that the direct overuse of antibiotics may not be the only way in which AMR is transmitted; animals carrying AMR genes in their microbiomes can interact with those that do not, facilitating transmission of AMR genes between them. Complementary research in mammals will be needed to confirm these results and extrapolate the findings to humans.
The American Society for Microbiology is one of the largest professional societies dedicated to the life sciences and is composed of 36,000 scientists and health practitioners. ASM’s mission is to promote and advance the microbial sciences.
ASM advances the microbial sciences through conferences, publications, certifications, educational opportunities and advocacy efforts. It enhances laboratory capacity around the globe through training and resources. It provides a network for scientists in academia, industry and clinical settings. Additionally, ASM promotes a deeper understanding of the microbial sciences to diverse audiences.
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