Researchers Uncover Potential Molecular Mechanism behind Caffeine’s Benefit to Sleep Deprivation-induced Cognitive Difficulties

Newswise — Article title: Caffeine-induced protein kinase A activation restores cognitive deficits induced by sleep deprivation by regulating O-GlcNAc cycling in adult zebrafish

Authors: Thuy-Duong Thi Tran, Jiwon Park, Dong Yeol Kim, Inn-Oc Han

From the authors: “Our collective findings underscore the interplay between [protein kinase A] signaling and O-GlcNAc cycling in the regulation of cognitive function in the brain, offering potential therapeutic targets for cognitive deficits associated with [sleep deprivation].”

This study is highlighted as one of April’s “best of the best” as part of the American Physiological Society’s APSselect program.