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Cell Model of Autosomal Dominant Polycystic Kidney Disease Catalogs Gene Mutations
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Article title: Polycystin-2-dependent transcriptome reveals early response of autosomal dominant polycystic kidney disease
Authors: Hyun Jun Jung, Eryn E. Dixon, Richard Coleman, Terry Watnick, Jeremy F. Reiter, Patricia Outeda, Valeriu Cebotaru, Owen M. Woodward, Paul A. Welling
From the authors: “[W]e created an inducible cell model of [autosomal dominant polycystic kidney disease] and assembled a catalog of genes that respond in immediate proximity to polycystin-2 depletion using transcriptomic profiling.”
This study is highlighted as one of November’s “best of the best” as part of the American Physiological Society’s APSselect program.
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